Drug for bone pharmacology MBBS medical quiz

 

1. Which of the following drugs is most commonly used to treat osteoporosis?

A) Calcium carbonate
B) Alendronate
C) Parathyroid hormone
D) Calcitonin

2. What is the mechanism of action of bisphosphonates like alendronate?

A) Increase osteoclast activity
B) Inhibit osteoblast activity
C) Inhibit osteoclast activity
D) Promote calcium absorption in the intestines

3. Which of the following is a side effect commonly associated with bisphosphonates?

A) Hypocalcemia
B) Gastrointestinal irritation
C) Hyperkalemia
D) Liver toxicity

4. Which drug is a recombinant form of parathyroid hormone used in osteoporosis treatment?

A) Teriparatide
B) Raloxifene
C) Denosumab
D) Cinacalcet

5. Which of the following drugs is used to inhibit bone resorption by acting as a RANKL inhibitor?

A) Denosumab
B) Calcitonin
C) Teriparatide
D) Raloxifene

6. The primary use of calcitonin in bone disorders is to treat which condition?

A) Osteoporosis
B) Paget’s disease
C) Hypercalcemia
D) Osteomalacia

7. Which drug is a selective estrogen receptor modulator (SERM) used in osteoporosis treatment?

A) Raloxifene
B) Alendronate
C) Teriparatide
D) Calcium citrate

8. Which of the following is a contraindication for the use of selective estrogen receptor modulators (SERMs) like raloxifene?

A) Osteoporosis
B) Deep vein thrombosis
C) Paget’s disease
D) Hypercalcemia

9. What is the primary effect of teriparatide on bone?

A) Inhibits osteoclast activity
B) Stimulates osteoblast activity
C) Reduces bone turnover
D) Increases calcium absorption

10. Which of the following is an adverse effect of parathyroid hormone therapy such as teriparatide?

A) Hypercalcemia
B) Osteosarcoma
C) Bradycardia
D) Liver damage

11. Which of the following calcium salts is most commonly used for supplementation?

A) Calcium carbonate
B) Calcium phosphate
C) Calcium citrate
D) Calcium gluconate

12. Vitamin D analogs are commonly used to treat which condition related to bone metabolism?

A) Osteoporosis
B) Osteomalacia
C) Hypercalcemia
D) Paget’s disease

13. Which of the following drugs is a bisphosphonate that is administered via intravenous infusion for the treatment of osteoporosis?

A) Ibandronate
B) Alendronate
C) Zoledronic acid
D) Risedronate

14. The mechanism of action of calcitonin in the treatment of Paget’s disease is:

A) Inhibition of osteoclast activity
B) Stimulation of osteoblast activity
C) Prevention of bone resorption
D) Inhibition of vitamin D synthesis

15. Which of the following drugs should be avoided in patients with a history of renal impairment when treating osteoporosis?

A) Alendronate
B) Teriparatide
C) Zoledronic acid
D) Raloxifene

16. Which of the following is the most important contraindication for the use of denosumab?

A) Pregnancy
B) History of osteosarcoma
C) Hypocalcemia
D) Hypercalcemia

17. The use of bisphosphonates is contraindicated in which of the following conditions?

A) Hypercalcemia
B) Peptic ulcer disease
C) Esophageal disorders
D) Chronic kidney disease

18. Which of the following drugs is used to treat hypercalcemia associated with malignancy?

A) Pamidronate
B) Calcium carbonate
C) Raloxifene
D) Calcitonin

19. Which drug is used for the treatment of Paget's disease of bone?

A) Teriparatide
B) Denosumab
C) Alendronate
D) Raloxifene

20. Which of the following is true regarding the use of teriparatide?

A) It is a bisphosphonate
B) It increases bone resorption
C) It stimulates osteoblast activity
D) It inhibits osteoclast activity

21. Which of the following drugs is commonly used in the management of osteomalacia?

A) Alendronate
B) Calcium and vitamin D supplements
C) Denosumab
D) Zoledronic acid

22. What is the primary action of teriparatide on bone?

A) Inhibition of bone resorption
B) Stimulation of bone formation
C) Stimulation of osteoclast activity
D) Inhibition of calcium absorption

23. Which of the following drugs is contraindicated in patients with Paget's disease who have a history of hypercalcemia?

A) Calcitonin
B) Raloxifene
C) Zoledronic acid
D) Teriparatide

24. Which drug is primarily used for preventing bone loss in postmenopausal women?

A) Raloxifene
B) Alendronate
C) Teriparatide
D) Denosumab

25. Which of the following drugs works by inhibiting the differentiation and activity of osteoclasts?

A) Raloxifene
B) Bisphosphonates
C) Teriparatide
D) Calcitonin

26. Which of the following is a common side effect of denosumab?

A) Osteonecrosis of the jaw
B) Hypercalcemia
C) Liver toxicity
D) Weight gain

27. Which of the following drugs is administered subcutaneously for the treatment of osteoporosis?

A) Denosumab
B) Alendronate
C) Raloxifene
D) Teriparatide

28. What is the most common adverse effect of bisphosphonates?

A) Gastrointestinal irritation
B) Weight loss
C) Hypertension
D) Renal failure

29. Which of the following drugs should be avoided in patients with chronic kidney disease due to the risk of nephrotoxicity?

A) Teriparatide
B) Zoledronic acid
C) Calcitonin
D) Raloxifene

30. Which drug is commonly used to treat hypercalcemia of malignancy?

A) Alendronate
B) Raloxifene
C) Pamidronate
D) Zoledronic acid

31. The main mechanism of action of raloxifene in bone health is:

A) Inhibition of osteoclast activity
B) Stimulation of osteoblast activity
C) Estrogen-like effects on bone
D) Increase in calcium absorption

32. Which of the following is an adverse effect of long-term use of bisphosphonates?

A) Osteonecrosis of the jaw
B) Gastrointestinal bleeding
C) Hypercalcemia
D) Liver damage

33. Which of the following medications is used to treat osteoarthritis and has bone-protective effects?

A) Glucosamine sulfate
B) Teriparatide
C) Raloxifene
D) Allopurinol

34. Which of the following bone-related drugs is used as an anabolic agent in osteoporosis treatment?

A) Alendronate
B) Denosumab
C) Teriparatide
D) Raloxifene

35. Which of the following is true regarding the administration of bisphosphonates?

A) Bisphosphonates should be taken with food
B) Bisphosphonates should be taken with a full glass of water
C) Bisphosphonates are absorbed best with fatty meals
D) Bisphosphonates should be taken just before bedtime

36. Which of the following is a rare but serious complication associated with bisphosphonates?

A) Osteoporosis
B) Osteonecrosis of the jaw
C) Hypercalcemia
D) Renal failure

37. What is the main role of vitamin D in bone health?

A) Inhibits bone resorption
B) Increases calcium and phosphate absorption
C) Stimulates osteoblast activity
D) Reduces calcium excretion

38. Which of the following drugs is primarily used for treating hyperparathyroidism-related bone diseases?

A) Cinacalcet
B) Calcitonin
C) Teriparatide
D) Bisphosphonates

39. Which of the following drugs can be used to treat osteoporotic fractures?

A) Denosumab
B) Alendronate
C) Calcium and vitamin D supplements
D) All of the above

40. What is the primary advantage of using zoledronic acid for osteoporosis treatment?

A) Oral administration
B) Long half-life
C) Rapid onset of action
D) It does not cause gastrointestinal side effects